Mon, 18 Dec 2017

Spectrophotometric Estimation of Tolperisone Hydrochloride and Diclofenac Sodium in Synthetic Mixture By Derivative Spectroscopic Method

 

Hiral H. Patel*1, Paresh U. Patel1.

1. Department of Pharmaceutical Analysis, Center for Health and Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.


 

ABSTRACT

The present manuscript describes simple, sensitive, rapid, accurate, precise and economical derivative spectroscopic method for the simultaneous determination of tolperisone hydrochloride (TOL) and diclofenac sodium (DIC) in bulk and synthetic mixture. Derivative spectroscopy offers a useful approach for the analysis of drugs in mixtures. In this study a first-derivative spectroscopic method was used for simultaneous determination of tolperisone hydrochloride and diclofenac sodium using the zero-crossing technique. The measurements were carried out at wavelengths of 250.60 and 311.20nm for tolperisone hydrochloride and diclofenac sodium respectively. The method was found to be linear (r2>0.9970) in the range of 5- 40 μg/ml for tolperisone hydrochloride at 250.60 nm. The linear correlation was obtained (r2>0.9990) in the range of 5-50 μg/ml for diclofenac sodium at 311.20 nm. The limit of determination was 0.65 and 0.55 μg/ml for tolperisone hydrochloride and diclofenac sodium respectively. The limit of quantification was 2.01 and 1.67 μg/ml. The method was successfully applied for simultaneous determination of tolperisone hydrochloride and diclofenac sodium in binary mixture.

Keywords: Diclofenac sodium, Tolperisone hydrochloride, Derivative spectroscopic method, Zero-crossing point.


[PDF]  Viewed: 1084  Downloaded: 138
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter