Tue, 19 Dec 2017

QSAR study of Antifungal activity of some Heterocyclic Compounds

 

Santosh Tiwari1*, Vikash Pandey1, Shailja Sachan2

1. Department of Chemistry, A.P.S.University, Rewa, (Madhya Pradesh) - India

2. Department of Chemistry, Govt. M.S.G. College, Rewa, (Madhya Pradesh) - India


 

ABSTRACT

QSAR analysis on a set of heterocyclic derivatives for antifungal activity was performed by using multiple regression procedure. The activity contribution of these compounds was determined from regression equation and the validation procedure to analyze the predictive ability of QSAR model was described. High agreement between experimental and predicted inhibitory values was obtained. The results of this study indicate that the parameter has a significant effect on antifungal activity of this class of compounds, thus simplifying design of new biologically active molecules.

Keywords: Quantitative structure-activity relationship, Antifungal activity, Multiple linear regressions


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