Tue, 19 Dec 2017

Formulation, evaluation and optimization of floating tablets of Valacyclovir Hydrochloride

 

Vishnumoorthi.M*1, Shripathy D1, A R Shabaraya1, SrinivasHebbar1Krishnanada Kamath1

1. Department of pharmaceutics, Srinivas College of pharmacy, Valachil, Farengipete post, Mangalore TQ -574143.


 

ABSTRACT

Gastro retentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastro intestinal tract (GIT) for local and systemic effect. The present study has been a satisfactory attempt to formulate floating drug delivery system of Valacyclovir, an orally administrated antiviral drug with a view of improving its oral bioavailability and giving sustained release of the drug. In present study design expert trial 8.0.6.1 software is used for designing of experiment. In central composite design based on response surface methodology yielded nine experimental runs. These nine formulations are evaluated for precompressional parameters like bulk density, tapped density, angle of repose and carr’s index. Formulations are also evaluated for postcompressional parameters like hardness, thickness, weight variation etc. all the formulations shows results in the acceptable range. All preliminary formulations are subjected to invitrobouyancy and dissolution study. The data obtained from the in vitro release study was fit to various kinetic models to explain the release profile of the drug. Kinetic models used were zero and first-order equations, Krosmeyersand peppas and Higuchi models. Based on results obtained from the prelimimary formulations five optimized formulations are selected and validated. Short-term stability study was done for optimized formulations.

Keywords: Valacyclovir, floating drug delivery, In vitro release, kinetic models, in vitro buoyancy, optimization.


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