Tue, 19 Dec 2017

Effect of Tecoma Stans Leaves Extract on Experimentally Induced Renal Injury In Various Animal Models

 

Shanmukha I1, Abubaker Siddiq2, Prabhu K3, Ramachandra Setty S4*

1.Dept. of Pharmacology, S.C.S. College of Pharmacy, Harapanahalli, Karnataka, India

2.Dept. of Pharmacology, S.J.M.College of Pharmacy, Chitradurga, Karnataka, India

3.Dept. of Pharmacognosy, S.C.S. College of Pharmacy, Harapanahalli, Karnataka, India

4.Dept. of Pharmacology, Govt. College of Pharmacy, Bengaluru, Karnataka, India


 

ABSTRACT

In the current investigation, we have assessed the nephroprotective activity of the 70% ethanolic extract of Tecoma stans leaves (EETSL) against cisplatin, gentamicin and paracetamol (nephrotoxicants) induced nephrotoxicity in rats. Nephrotoxicity is confirmed by elevated kidney weight, blood urea, serum creatinine, lipid peroxidation (LPO), decreased tissue glutathione (GSH) and body weight levels at the administered doses. The ethanolic extract produced reduction in kidney weight, blood urea, serum creatinine, LPO levels and reversed the depleted GSH levels and body weight. This is further confirmed by histopathological studies. The results of the present study reveals that the ethanolic extract of Tecoma stans leaves significantly inhibited the cisplatin, gentamicin and paracetamol induced renal damage in rats and this may be attributed to its antioxidant properties.

Key words: Tecoma stans, Lipid peroxidation, GSH, Cisplatin, Gentamicin, Paracetamol, Renal injury.


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