Tue, 21 Nov 2017

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION AND QSAR STUDIES OF THIOPHENE AND ARYL SUBSTITUTED COMPOUNDS

Mohammad Anwar Hussain1*, Basavaraja H S1, Jayadevaiah K V1, Mumtaz M Hussain1, Mohammad Saqib2, Mohammed Waseem2

 

1.S J M College of Pharmacy, Chitradurga, Karnataka- 577 502, India

2. RMES’S College of Pharmacy, Gulbarga, Karnataka - 585 102, India


ABSTRACT

 

A series of thiophene and aryl substituted compounds 1a-f; 2a-b and 3a-c were synthesized by Erlenmeyer azolactone synthesis. These compounds were screened for antimicrobial activity method in vitro. Among the tested compounds 3c showed significant activity and some of the other compounds showed promising activity. The structure of new compounds synthesized during present investigation have been authentically established by their IR,1H NMR and Mass spectra and some QSAR studies.

Key words: Thiophene; antimicrobial; antibacterial; antifungal.


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