Tue, 21 Nov 2017

DEVELOPMENT AND EVALUATION OF A SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF A HERBAL EXTRACT

M. K. Kale1*, P. B. Suruse1, S. P. Warke2

 

1. Sharad Pawar College of Pharmacy, Wanadongari, Hingna Road, Nagpur (MS), INDIA

2. KYDSCT’S College of Pharmacy, Sakegaon, Bhusawal, Jalgaon, (MS), INDIA


ABSTRACT

 

The aim of this work was to develop a stable self micro emulsifying drug delivery system (SMEDDS) of herbal extract and evaluating its in vitro potential. The solubility of herbal extract was determined in various vehicles. Pseudoternary phase diagrams were used to evaluate the micro emulsification existence area. Release rate of herbal extract was investigated using a dissolution method. SMEDDS were characterized for clarity, precipitation and particle size distribution. Formulation development and screening was done based on results of solubility & from phase diagram. The optimized formulation used for in vitro dissolution was composed of herbal extract (30 %), Cremophor RH 40 (40 %), Plurol Oleique (30%). The SMEDDS formulation showed complete release in 10 min. as compared with the plain extract and conventional marketed formulation. SMEDDS subjected to various were conditions of storage as per ICH guidelines for 3 months. SMEDDS successfully withstood the stability testing. It has been found that dissolution profile of herbal extract from SMEDDS was much improved. SMEDDS appeared to be an interesting approach to improve solubility, and ultimately bioavailability

Key words: SMEDDS; herbal extract; Pseudo-ternary Phase diagram; Self-emulsification


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