Sun, 17 Dec 2017

A Modified Release Drug Delivery Device: Multilayered Matrix Tablets

 

Izhar Ahmed Syed1*, Yamsani Madhusudan Rao 2.

 

1. SR College of Pharmacy, Ananthsagar , Hasanparthy Warangal -506371.

2. University College of Pharmaceutical Sciences, Kakatiya University , Warangal


 

ABSTRACT

A new multi-layer tablet design has recently been proposed for constant drug release: It consists of a drug-free barrier layer on one or both bases of an active core (hydrophilic matrix). This partial coating modulates the core hydration process and reduces the surface area available for drug release. The consequence is an extended release that draws close to a linear release profile. These devices are primarily intended for soluble drugs, while an excessive reduction of the release rate may be obtained with drugs of low solubility. In these devices, time-dependent polymeric barrier is planned to control the release of soluble drugs. Oral Controlled release matrix tablets and layered matrix tablets can be formulated for highly water soluble drugs and sparingly soluble drugs by using polymers in the matrix core and as release retardant layers. This devices delivery the drugs to the colon. This review focuses on the application of the multilayered matrix tablets in the design of controlled released dosage forms employing various types of polymers and layered on the matrices core.

Key words: Matrix core, multilayered matrix tablets, zero order release, release retardant layers

 


[PDF]  Viewed: 1757  Downloaded: 321
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter