Sun, 17 Dec 2017

Rapidly Disintegrating Tablet: A Potential Concept of Modern Formulation Technology

 

Ranu Biswas*, Avik Dutta

 

1. Gupta College of Technological Sciences, G.T.Road, Ashram More, Asansol-713301, Burdwan, West Bengal, India.


 

ABSTRACT

Development of fancy oral drug delivery systems has always attracted scientists because of improved patient compliance. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems. A fast-dissolving drug delivery system, in most cases, is a tablet which is designed to allow administration in the mouth in the absence of water and readily dissolves or disintegrates in the saliva generally within <60 seconds with rapid dissolution of drug and absorption of which may produce rapid onset of action and ease of administration to patients who refuse to swallow a tablet, such as pediatric and geriatric patients and psychiatric patients. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. The risk of chocking or suffocation during oral administration is avoided, thus providing improved safety. Several techniques have been developed in the recent past, to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This article focuses on the technologies available and the advances made so far in the field of fabrication of mouth dissolving tablets. Apart from the conventional methods of fabrication, this review also provides the detailed concept of some unique patented technologies like Zydis, Lyoc, Quicksolv, Orasolv, Durasolv, Flashtab, Oraquick, Wowtab and Ziplet along with their advantages and limitations.

Key words: Rapidly Disintegrating Tablet, Mouth Dissolving Tablet, Fast Disintegrating Tablet, Fast Dissolving Tablet, Orally Disintegrating Tablet, Orodispersible Tablet.


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