Sun, 17 Dec 2017

Comparative Tableting Properties of Three Local Potato Starches III: The Disintegrant Properties

 

J. Muazu1*, H. Musa2, A. B. Isah2, P. G. Bhatia2

 

1. University of Maiduguri, Nigeria

2. Ahmadu Bello University, Zaria, Nigeria


 

ABSTRACT

This study aimed at comparing the disintegrant properties of three potato starches with Maize starch BP as well as effect of method of incorporation of disintegrant on release of paracetamol tablet formulation. The disintegrant property was assessed by both disintegration and dissolution times of the formulation. The results showed that tablets produced with potato starch were similar in disintegration and dissolution times with those formulated with Maize starch BP. Disintegrants employed extra-granularly showed better disintegration than intra-granular or intra-extra-granular. Therefore the potato starches can be used as a disintegrant in paracetamol tablets formulation

Keywords: disintegrants, potato starch, formulation, dissolution time, incorporation


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