DOI: 10.21276/ajptr
Fri, 19 Apr 2019

Usage of Alteplase in Stroke Patients in Rural Tertiary Care Hospital: An Observational Study


Jagadish Babu.Dasari*1, Jyothi.K2


1. Department of Clinical pharmacy, SAC College of pharmacy, Karnataka, India.



The aim of the study is to assess the usage of alteplase in stroke patients which is second leading cause in worldwide. Its beneficial effect in stroke patients is to disperse the thrombus within an occluded cerebral vessel and to limit ischemic damage within surrounding tissue (ischemic penumbra) and is safety and efficacy towards the stroke patient. This is prospective observational study, which assed the current usage of tissue Plasminogen activator (tPA) alteplase in stroke patients. This study was conducted in Stroke patients in Adichunchanagiri Hospital and Research Center. Duration of our study is sixteen months. A total of 140 stroke patients were assigned to receive alteplase. In which 102 (72.85%) Patients were treated before 3 hours (Window period) the study population were elderly with the age between 53-57 were 40.70% (n=48), and followed by 63-67 were 22.03 % (n=26), where as in female elderly patients the age group between 48-52 were 59.10% (n=13) and followed by 53-57 were 18.18 (n=4), elderly patients are more prone to have stroke. Therefore 54.23% (n=64) were recoverd in the post intervention benefit of alteplase in stroke patients,as in female patients were 68.18% (n=15) and age between 78-82 years only one patient died during the treatment. This study shows that efficacy and safety of thrombolytic in stroke patients within 3 hours and recover of the patients from the stroke is high rate. The findings encourages wider use of thrombolytic therapy for suitable patients treated in stroke centres can be a beneficial in future endeavours.

Keywords: Alteplase, Stroke Patients and Thromobolytic.

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