Sun, 17 Dec 2017

Synthesis and Biological Evaluation of 2-(1h-Benzotriazol-1-Yl) Acetohydrazide Containing Isatin Derivatives

 

B. V. Suma*1, Surendra Kumar1, C. H. S. Venkataramana1, Judy Jays1, V. Madhavan2

 

1. Department of Pharmaceutical Chemistry, M. S. Ramaiah College of Pharmacy, M.S.R.I.T. Bangalore – 560054, India.

2. Department of Pharmacognosy, M. S. Ramaiah College of Pharmacy, M.S.R.I.T., Bangalore – 560054,India.


 

ABSTRACT

Benzotriazole was condensed stoichiometrically with ethyl chloro acetate in presence of potassium carbonate. The resulting ethyl-1H-benzotriazole-1yl-acetate was reacted with hydrazine hydrate in ethanolic solution. The resulting 2-(1H-benzotriazole-1-yl) aceto hydrazide was characterized by physical data and spectral studies and further it was condensed with 1H-indole-2,3-dione derivatives to form 2-(1H-benzotriazole-1-yl)-N'-[(3Z)-2-oxo-1,2-dihydro-3H-indol-3-ylidene] aceto hydrazide derivatives. These derivatives were characterized by melting point, TLC, IR, 1H-NMR and Mass spectrum. From the biological activity profile it was revealed that they have considerable anti-inflammatory activity & antimicrobial activity against S. aureus, B. subtilis, Klebsiella and E. Coli.

Keywords: Indole-2, 3-diones, Benzotriazole, Antimicrobial and invitro anti-inflammatory activities;

 


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