Sun, 17 Dec 2017

Comparative Evaluation Studies of Natural Superdisintegrants for Fast Dissolving Tablets of Gliclazide

 

Rajeshree Panigrahi1*, K.A.Chowdary2, Gitanjali Mishra3, Manas Bhowmik4, Saiprasanna Behera1

 

1.      Royal College of Pharmacy and Health Sciences - Berhampur

2.      St. Ann’s college of Pharmacy, Cantonment- Vizianagram

3.      Dept of Zoology, Berhampur University- Berhampur

4,     Associate Professor, Himalayan Institute of Pharmacy, Sikkim


 

ABSTRACT

The main objective of this study was to formulate and evaluate the fast dissolving tablets of Gliclazide with natural superdisintegrants. Various formulations were prepared by direct compression using different concentrations of natural superdisintegrant i.e. isolated mucilage of Plantago ovata, isolated mucilage of Aloe vera and extracted mucilage of Hibiscus rosasinesis. The initial compatibility studies between the drug and excipients were carried out using FTIR spectroscopy. The blend was evaluated for additive properties. The tablets were evaluated for physical parameters and in vitro drug release. The disintegration time and in vitro drug release of optimized formulation (P4) was found to be 2.41±0.05 secs. The optimized formulation was subjected to stability studies for three months. The formulation was found to be stable, with insignificant change in the hardness, disintegration time, drug content and in vitro drug release pattern.

Keywords: Fast dissolving tablet, isolated mucilage of Plantago ovata, isolated mucilage of Aloe vera and mucilage of Hibiscus rosasinesis

 


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