DOI: 10.21276/ajptr
Sun, 21 Apr 2019

Synthesis of Bis-Amide and Hydrazide containing Derivatives of Malonic Acid and Hypophosphorousadducts of Acidhydrazones Derived from 2-[(N-Acetyl) 2, 5-Dichloroanilido] Acetohydrazide


Raj Narayan Sharma1*, K. P. Sharma2, S. N. Dikshit3


1. Department of Chemistry, BVM College of Tech. and Management

2. SMS Govt.Model Science College, (Jiwaji university) Gwalior-474002 (MP) India.



We synthesized a new series of bis-amide and hydrazide-containing derivatives of malonic acid and hypophosphorousadducts of acid hydrazones by the reaction of 2-[N- (acetyl) 2, 5-dichloroanilido acetohydrazide with various Carbonyl Compounds in 31 to 64% yield.  Newly synthesized compounds have been tested for their anti-bacterial activity against gram positive bacteria S.albus, S.aureus and gram negative bacteria E.coli and Pseudomonas piosineus. The compound (1, 2, 3, 7, 10, 12, 15) shown significant activities and compound (4, 9, 13, 14, 17) have shown moderate activity. The same compounds were tested for their anti-fungal activity against Candida albicans, Aspergillus niger and Alternaria alternata at concentration of 30 mg/ml using Savored dextrose agar media. The compound (3, 5, 9, 11, 14) shown significant activities and compound (2, 4, 6, 13, 16) have shown moderate activity against Candida albicans and Aspergillus niger. All the other compounds did not show significant activity against the fungi at the concentration used.

Keywords: Malonic acid, bis-amides, acid hydrazides, hydrazones, hypo phosphorous adducts

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