Sun, 17 Dec 2017

Quantitative Estimation of Carbimazole by UV Derivative Spectrophotometry in Bulk Drug and Tablet Formulation

 

Avinash V. Deosarkar*1, Shruti D. Deshpande1, Sanjay G. Walode1

 

1. Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala -410401, University of Pune, (Pune), Maharashtra, India


 

ABSTRACT

Development and validation of an analytical UV derivatives spectrophotometric method to quantify carbimazole as a single active principle in pharmaceutical formulation were done. Based on the spectrophotometric characteristics of carbimazole, a signal of first (314 nm), second (300 nm), third (289 nm), fourth (320 nm) order derivative spectrum was found to be adequate for quantification. The method obeyed Beer's law in the concentration range of (2-18 µg/ml) with square correlation coefficient (r2 = 0.999). The mean percentage recovery was found to be 99.56 ± 0.7179. As per ICH guidelines the results of the analysis were validated in terms of linearity, precision, accuracy, limit of detection and limit of quantification, and were found to be satisfactory.

Key Words: Carbimazole, Derivative spectrophotometry, ICH, Validation.


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