Sun, 17 Dec 2017

Antidepressant Activity of Curcumin Loaded Solid Lipid Nanoparticles (C-SLNs) In Mice

 

Vandita Kakkar1, Indu Pal Kaur2*

 

1. Doctoral Research Fellow, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India, 160014.

2. Associate Professor, Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India, 160014.


 

ABSTRACT

Curcumin a hydrophobic poly-phenol is derived from turmeric, the rhizome of the herb Curcuma longa L. Curcumin has been shown to exert anti-depressant effects in rodent models. However, poor bioavailability of curcumin curbs its usage as a therapeutic agent. In view of the above curcumin loaded solid lipid nanoparticles (C-SLNs) were prepared and evaluated for the antidepressant effect of acute administration of C-SLNs (1, 2.5, 5 and 10 mg/kg, p.o.) in the forced swim model of depression in mice. C-SLNs exhibited 47.42%, 67.39%, 31.67% and 36.2% reduction in immobility time after administration of 1, 2.5, 5 or 10 mg/kg dose (p.o.) respectively. Free curcumin however did not result in a significant reduction, except at 2.5 mg/kg, which could produce a reduction of 21.7% but was still 2.83 times lower than the effect obtained with a similar dose of C-SLNs. The results obtained may be assigned to the therapeutic amounts of curcumin reaching the brain. Thus, C-SLNs with their improved bioavailability and permeability possess higher anti-depressant potential upon administration of a single and a much lower dose when compared to free curcumin.

Keywords: Curcumin, solid lipid nanoparticles, antidepressant, bioavailability, forced swim test


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