Sun, 17 Dec 2017

Peucedanum grande attenuates acute renal failure and oxidative stress induced by Mercuric chloride in rodents

 

Mohammad Aslam1*, Shiekh Tanveer Ahmad2, Asia Asiaf3, Kalim Javid4, Rameshver Dayal5, Surender Singh6

 

1. Department of Ilmul-Advia, Faculty of Medicine (U), Jamia Hamdard, New Delhi-110062.

2. Section of Molecular Carcinogenesis & Chemoprevention, Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi-110062.

3. Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, J&K-190006.

4. Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062.

5. Head Chemistry Division, Forest Research Institute, Dehradun, Uttranchal.

6. Department of Pharmacology, AIIMS, Ansari Nagar, New Delhi-29.


ABSTRACT

Peucedanum grande has been found to be associated with the multiple therapeutic properties. In the present study, we have used P. grande as an ameliorating agent against nephrotoxic effects of Mercuric chloride (HgCl2). The rats were given pretreatment of P. grande orally at a dose of 60 and 120 mg/kg body weight for five consecutive days. Mercury chloride 4 mg/kg body .wt was used as renal toxicant, and injected subcutaneously in the neck region in a volume of 1 ml/kg. The modulatory effects of P. grande on HgCl2 induced nephrotoxicity was investigated by assaying oxidative stress biomarkers, lipid peroxidation, serum kidney toxicity markers and by histopathological examination of kidney. The HgCl2 induced nephrotoxicity by depleting antioxidant levels, elevating the level of serum creatinine and BUN, as well as damaging the normal architecture of kidney. P. grande pretreatment prevented deteriorative effects induced by HgCl2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological change against HgCl2 administration.

Keywords: Peucedanum grande, Mercuric chloride, Kidney, histopathology, oxidative stress.

 


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