Sun, 17 Dec 2017

Design, Preparation and Characterization of Cyclodextrin Inclusion Complexes of Glimipiride

 

Anilkumar J. Shinde,*1  Manoj  B. Paithane,1 Vinod S. Ingole,1 Harinath N. More1

 

1. Dept. of Pharmaceutics, Bharati Vidyapeeth college of pharmacy, Kolhapur (M.S), India


 

ABSTRACT

Over the years, inclusion complexation of drugs with β-cyclodextrin has emerged as a viable attempt to improve the dissolution of water insoluble drugs. The aim of the present work was to improve the dissolution rate of Glimepiride, by inclusion complexation with β-cyclodextrin. The stoichiometric ratio determined by phase solubility analysis for inclusion complexation of glimepiride with β-cyclodextrin was 1:1, 1:2, & 1:5. The solubility of glimepiride increased with increasing amount of β-cyclodextrin in water. Complexes of glimepiride were prepared with β-cyclodextrin by kneading method and physical mixture. The complexes were characterized by Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) patterns. These studies indicated the inclusion of glimepiride in the cavity of β-cyclodextrin. The complexation resulted in a marked improvement in the solubility of glimepiride. An optimum increase in the dissolution rate of the drug was observed at a drug-polymer concentration of 1:5 concentrations. Mean dissolution time of glimepiride decreased significantly after preparation of complexes of glimepiride with β-cyclodextrin.

Keywords: Glimepiride, β-cyclodextrin, inclusion complexation, in vitro dissolution studies.

 


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