Sun, 17 Dec 2017

Formulation and In-Vitro Evaluation of Intra Pocket Drug Delivery Device Containing Gatifloxacin for Periodontitis

Mahesh Ingawale*, Shripathy D, A. R. Shabaraya, Bhavin M, Shantesh Masurkar, Jivan Kharat

 

1. Department of Pharmaceutics, Srinivas College of Pharmacy, Mangalore.


 

ABSTRACT

Dental implant is a pharmaceutical device in the form of strip with very small loading and size of 0.25 sq cm. For site-specific one-time continuous delivery of Gatifloxacin an antimicrobial compound with excellent activity against anaerobic micro-organism in the treatment of periodontal disease was prepared by solvent casting technique using ethyl cellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose K4M and Eudragit RL-100 with dibutylphthalate as plasticizer. The physicochemical parameters like thickness, weight variation, content uniformity and release characteristics were evaluated The drug release was initially high on day one to achieve immediate therapeutic level of drug in pocket, followed by marked fall in release by day two, and progressive moderate release profile to maintain therapeutic level following anomalous transport mechanism. Formulation F6 released 97.34% of drug at the end of 144 h and was considered as best formulation. In vitro antibacterial activity was carried out on Streptococcus mutans .

Keywords: Dental Implant, Gatifloxacin, In vitro, physicochemical, antimicrobial, streptococcus.


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