DOI: 10.21276/ajptr
Sun, 21 Apr 2019

Synthesis And Antimicrobial Activity Of Hepta-O-Benzoyl-β-D-Lactosyl-3-(2)-Hydrazino-1, 3-Benzothiazolyl Thiocarbamides


Renu B. Ghayalkar1* Naushad Zubair2, Shirish P. Deshmukh1


1. P. G. Department of Chemistry, Shri Shivaji College, Akola–444001. (M.S.) India.

2. P. G. Department of Microbiology, Shri Shivaji College, Akola–444001. (M.S.) India.



Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacological activities. Carbohydrate is the key element in variety of biological phenomena and its N-linked sugar derivatives also exhibit wide range of medicinal activities. Keeping in this view, when one biological active molecule is linked to another, the resultant molecule generally has increased potency.Hence for the first time, in present work, we have interacted two pharmocophores, hepta-O-benzoyl-β-D-lactosyl isothiocyanate  and substituted 2-hydrazino-1,3-benzothiazoles in acetone medium to yield hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides. The identities of these newly synthesised hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides have been established on the basis of usual chemical transformations and IR , 1H NMR and Mass spectral studies. The antibacterial and antifungal activities of also reported. Some of these derivatives exhibit significant antimicrobial activity.

Key words: Lactosyl isothiocyanate, hydrazino benzothiazoles, lactosyl hydrazino benzothiazolyl thiocarbamides, antimicrobial activity.

[PDF]   Viewed: 1592   Downloaded: 151
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter