Mon, 20 Nov 2017

The Analgesic Effect of Ethanolic Extract of Myristica Fragrans Houtt (Nutmeg) on Mice

Olorunfemi O. Joyce*1, Nworah D. Chinwe1, Chinko C.Bruno1, Joffa P. P. Kwaku2, Pughikumo D. Tabot2.

1.Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria.

2.Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.


ABSTRACT

The analgesic effect of the ethanolic extract of Myristica fragrans was studied in rats using the following models; Acetic acid induce writing, Thermal test (HOT PLATE), Formalin induced pain test. The results for all the models showed dose dependent and were significant (P<0.05). The control for acetic acid induced- writhing test showed 72+0.41, the extract at dose of 200mg/kg showed 34.25 + 0.85 while dose of 500mg/kg showed 20.5+65 and Aspirin drug group showed 3.5+ 0.65. There was an increase in pain threshold for thermal induced pain at 60mm pre-treatment. For the control group, the result showed 2.59  0.08 which was significant (P<0.05). When M. fragrans was given at 200mg/kg, the result was 8.75+ 0.72 and when given at dose 500mg/kg, the reaction time was 11.75 + 0.60. For the Aspirin drug group, the reaction time was 33.30 +1.52. The formalin induced pain was inhibited in both phases i.e 0-5mins and 15-30 mins, the result was still significant for both phases. The results for the control group were 97.25+0.48 and 90.5+0.65 for 0-5mins and 15-30mins respectively. For the extract (M. fragrans) at dose 200mg/kg the result for 0-5 min was 72.75 +0.48 and for 15-30 min, it was 44.75  1.32, at the dosage of 500mg/kg, the results were 57.5  0.65 and 31.75  0.72 at 0-5min and 15-30min respectively. The results for the aspirin drug group were 52.0 + 0.41 and 22.25 + 0.63 at 0-5min and 15-30min respectively. The results indicated that the analgesic effect of Myristica fragrans houtt (NUTMEG) ethanolic extract is both peripherally and centrally significant.

Keywords: Myristica fragrans houtt, Analgesic effects, Acetic acid writhing, Thermal test, formalin pain test, mice.


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