Mon, 20 Nov 2017

Comparative Anti-Diabetic Effects of Ocimium Gratissimum, Vernonia Amygdalina and Insulin on Testicular Architecture in Stz-Induced Diabetic Rats

 

Olorunfemi O. Joyce*1, Nworah D. Chinwe1, Egwurugwu J. Nnabufe2, Pughikumo D. Tabot3., Joffa P.P. Kwaku3.

1.Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria.

2.Department of Human Physiology, College of Medicine & Health Sciences, Imo State University, P.M.B. 2000, Owerri, Imo State, Nigeria.

3.Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.


 

ABSTRACT

To study the effects of ethanolic extracts of Vernonia amygdalina(VA) and Ocimum gratissimum (OG)on the testes of diabetic rats, thirty-two male rats were used. Control consisted of eight (8) rats which served as non- diabetic control, receiving sodium citrate daily. The remaining rats were injected intraperitoneally with streptozotocin(65mg/kg) to induce diabetes. The rats confirmed diabetic were randomly divided into three experimental groups (1, 2 and 3) made up of eight rats each. Group 1 received 6IU/kg of insulin. Group 2 was given 100mg/kg body weight of Vernonia amygdalina and 200mg/kg body weight of Ocimum gratissimum combined daily. Group 3 served as the diabetic control and was given distilled water. The entire investigation lasted for 6 weeks. Results revealed typical testicular architecture in the normal control. Diabetic control exhibited alteration of germinal epithelium, distortion of seminiferous tubules as well as vacuolation of seminiferous tubules. The effects of the extracts on diabetic rats’ testes showed improvements compared to the diabetic control group. It is therefore safe to speculate that the extracts of these plants used especially when combined exert some significant improvement in combating the adverse effects of diabetes on the testes of male rats.

Keywords: Vernonia amygdalina, Ocinum gratissimum, insulin, ethanolic extract, streptozotocin,diabetic, rats.


[PDF]  Viewed: 1238  Downloaded: 152
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter