DOI: 10.21276/ajptr
Mon, 27 May 2019

Comparative Anti-Diabetic Effects of Ocimium Gratissimum, Vernonia Amygdalina and Insulin on Testicular Architecture in Stz-Induced Diabetic Rats


Olorunfemi O. Joyce*1, Nworah D. Chinwe1, Egwurugwu J. Nnabufe2, Pughikumo D. Tabot3., Joffa P.P. Kwaku3.

1.Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria.

2.Department of Human Physiology, College of Medicine & Health Sciences, Imo State University, P.M.B. 2000, Owerri, Imo State, Nigeria.

3.Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.



To study the effects of ethanolic extracts of Vernonia amygdalina(VA) and Ocimum gratissimum (OG)on the testes of diabetic rats, thirty-two male rats were used. Control consisted of eight (8) rats which served as non- diabetic control, receiving sodium citrate daily. The remaining rats were injected intraperitoneally with streptozotocin(65mg/kg) to induce diabetes. The rats confirmed diabetic were randomly divided into three experimental groups (1, 2 and 3) made up of eight rats each. Group 1 received 6IU/kg of insulin. Group 2 was given 100mg/kg body weight of Vernonia amygdalina and 200mg/kg body weight of Ocimum gratissimum combined daily. Group 3 served as the diabetic control and was given distilled water. The entire investigation lasted for 6 weeks. Results revealed typical testicular architecture in the normal control. Diabetic control exhibited alteration of germinal epithelium, distortion of seminiferous tubules as well as vacuolation of seminiferous tubules. The effects of the extracts on diabetic rats’ testes showed improvements compared to the diabetic control group. It is therefore safe to speculate that the extracts of these plants used especially when combined exert some significant improvement in combating the adverse effects of diabetes on the testes of male rats.

Keywords: Vernonia amygdalina, Ocinum gratissimum, insulin, ethanolic extract, streptozotocin,diabetic, rats.

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