DOI: 10.21276/ajptr
Mon, 27 May 2019

Synthesis and Antimicrobial Activity of N-(5-Phenyl-1, 3, 4-Thiadiazole-2-yl) Benzamide/ Acetamide


Mohammad Saqib1*, Kishore Singh Chatrapati1, H. J. Kallur1, Mohammed Waseem1, Mohammad Anwar Hussain2. Shaikh Shadab Ismadar3.

1. RMES’s College of Pharmacy, Gulbarga - 585 102, Karnataka, India

2. SJM College of Pharmacy, Chitradurga - 577502, Karnataka, India

3. Luqman College of Pharmacy, Gulbarga - 585 102, Karnataka, India



In the present study, a series of N-[5-(phenyl)-1,3,4-thiadiazole-2-yl] benzamide and N-[5-(phenyl)-1,3,4-thiadiazole-2-yl] acetamide were prepared by refluxing with benzoyl chloride and acetyl chloride with 5-phenyl-1,3,4-thiadiazole-2-amine. 5-phenyl-1,3,4-thiadiazole-2-amine were prepared by oxidative cyclization of thiosemicarbazone (through condensation of aromatic aldehyde and thiosemicarbazide). The structure of new compounds prepared during present investigation have been authentically established by their IR,1H-NMR and Mass spectral studies. The antibacterial and antifungal activities of thiadiazole derivatives also reported. Some of these derivatives exhibit significant antimicrobial activity.

Key words:  Thiosemicarbazone, Thiadiazole, antibacterial, antifungal.

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