DOI: 10.21276/ajptr
Mon, 27 May 2019

Evaluation on Safety and Efficacy of A Polyherbal Antidiabetic Nutraceutical Formulation


Suresh. J*1, Sri Vasavi Reddy. A1, Hemanth. KSY2, Mruthunjaya. K1. Nagamani N3

1. Department of Pharmacognosy1, JSS University, Mysore, Karnataka, India.

2. Department of Pharmaceutics2, JSS University, Mysore, Karnataka, India.

3. JSS Ayurveda Medical College, Mysore, Karnataka, India.



In the present study, the polyherbal antidiabetic nutraceutical formulation was screened for its safety and efficacy using albino wistar rats (130-150gm). The formulation consists of Gymnema sylvestre, Trigonella foenum-graecum, Allium cepa, Curcuma longa, Phyllanthus amarus, Tinospora cordifolia, Eugenia jambolana, Cinnamomum zeylanicum. The safety of the formulation was studied by acute toxicity studies according to Organisation for Economic Co-operation and Development (OECD) guidelines and efficacy was studied by using streptozotocin induced diabetes model at 45 mg/kg b.w. The test drug did not show any signs of toxic­ity or mortality up to 5000 mg/kg which was fixed as the cut off point for the maximum tolerated dose.  Antidiabetic activity was screened in streptozotocin induced diabetic rat model for 21 days using glibenclamide 1.5 mg/kg as standard and parameters like blood glucose level and weight variation were studied. After 21 days treatment the mean blood glucose level of the formulation, dose 1 (500mg/kg) treated group showed 142.50±1.11mg/dl, the formulation, dose 2 (250mg/kg) treated group showed 210.66±2.96 mg/dl, the standard group showed 137.66±2.10 mg/dl, Control group 433.33±9.89mg/dl, Normal group 94.83±0.30 mg/dl respectively and at a dose of 500mg/kg body weight. The formulation showed significant increase in the body weight. Therefore, the results indicated that the polyherbal neutraceuticals formulation is an efficacious and safer antidiabetic/ oral hypoglycemic formulation in Type II diabetes.

Keywords: Nutraceutical formulation, acute toxicity study, streptozotocin, antidiabetic activity.

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