Sat, 18 Nov 2017

Satranidazole Biodegradable Inserts For Local Long Term Treatment of Periodontitis

 

Shankrayya M1*, Mukthar Ahemad Javali2, Santoshkumar R G1, Venkatesh J S1Nagesh C3,

1.S.C.S*. College of Pharmacy, Harapanahalli-583131.Karnataka. India.

2.Al-badar Rural Gulbarga Dental College and Hospital.Gulbarga. Karnataka. India.

3.Maratha mandal’s college of pharmacy. Belgaum. Karnataka. India.


 

ABSTRACT

An attempt has been made in the present research to formulate periodontal inserts of  Satranidazole (STZ) to increase residence time and prolong drug release. The periodontal inserts were prepared using chitosan, a natural biodegradable polymer. Chitosan inserts containing Satranidazole (10%, 20% and 30% to the weight of polymer) were prepared by solution casting method using 1% v/v acetic acid in water. Further inserts containing 30% Satranidazole were cross-linked by exposing to the vapours of 2% v/v glutaraldehyde in water for two different time period of 2 and 4 hours to retard the release of drug. FTIR and DSC studies revealed that there was no interaction between drug and polymers. The inserts were then evaluated for their physicochemical parameters like uniformity of thickness, weight, folding endurance, % moisture loss, tensile strength; drug content and in vitro drug release studies.  In vitro drug release data indicated that the films showed an initial burst release followed by sustained release of the drug. The drug-loaded films that were not cross linked had released the drug up to 10 days and the films which were cross linked for different duration showed a progressive fall in the release of the drug and extended up to 18 days.

Keywords: Satranidazole, cross-linking, chitosan, periodontal insert.


[PDF]  Viewed: 1204  Downloaded: 139
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter