Thu, 24 Apr 2014

Inhibition of cancer cell growth by crude ethanolic extract of Tinospora malabarica (Miers) Ann. An endangered medicinal plant

 

David Punitha1, Madathupatti Ramanathan Udhayasankar2, Uthaman Danya2, Karupannan Arumugasamy1* , Sreenivasapuram Natarajan Suresh3

1. Department of Botany, Providence College for Women, Coonoor, The Nilgiris, Tamilnadu, India.

2. PG and Research Department of Botany, Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India.

3. PG and Research Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India.


 

ABSTRACT

An ethanolic extract of Tinospora malabarica (Menispermaceae) was studied for its effects on growth in two malignant cell lines including a Human Melanoma cancer cell lines (A 375) and Skin cancer cell lines (A 431) using MTT assay. In these cell lines studied, the extract decreased cell viability, inhibited cell proliferation, and induced cell death in a dose dependent manner. The ethanolic extract of T. malabarica showed good cytotoxicity and IC50 value of 49.87μg/mL and 112.54 µg/mL respectively. It could be a reliable source of potent pharmacophore for treatment of disease like cancer.

Keywords: Tinospora malabarica, Ethanol extract, Melanoma cancer and Skin cancer.

 


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