Mon, 20 Nov 2017

Formulation and Evaluation of Parenteral Dosage Form of Lornoxicam Using Hydrotropic Solubilization Method

 

Nagaraja YS*1, Nagaraj TS1., Bharathi DR1, Mahantesha MK1, Manjunatha TO1

1. Department of Pharmaceutics, S.J.M College of Pharmacy, Chitradurga-577502, Karnataka, India.


 

ABSTRACT

Lornoxicam is comparatively a new non-steroidal anti-inflammatory drug, which is selective cyclooxygenase-1 and 2 (COX 1 and 2) inhibitors. Lornoxicam is a non steroidal anti-inflammatory drug that exhibits its anti inflammatory, analgesic and anti pyretic activities in animal models and it is presently available in the market only as tablet dosage form. It is preferred in the treatment of adults with osteoarthritis, acute pain rheumatoid arthritis, postoperative dental pain and primary dysmenorrhoea. The present study was undertaken with an intention to develop a stable and effective parenteral formulation, containing the drug Lornoxicam. Lornoxicam is a light sensitive and insoluble water soluble drug but unstable at higher temperature in water. So the effects of various co solvents in the solubility of  Lornoxicam have been evaluated. Lornoxicam was tried with co solvents such as PEG-400, β-cyclodextrin and Sodium Lauryl sulphate. The drug was made into injection formulation for administered as a SVP. Various batches of Lornoxicam injection formulation were prepared in order to assess the influence of heat, light, atmospheric oxygen and antioxidant on the stability of the drug and the formulations were also subjected to accelerated stability test. Out of all trials, formulation containing Sodium Lauryl sulphate was found to be more soluble, stable and passed all tests satisfactorily.

Keywords: Lornoxicam, osteoarthritis, β-cyclodextrin, dysmenorrhoea, Sodium Lauryl sulphate


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