Mon, 20 Nov 2017

Formulation and Evaluation of Solid Self Micro Emulsifying Drug Delivery System of Lamotrigine

 

Ravali Goli1*, Chaitali Katariya1, Shilpa Chaudhari1.

1. Department of Pharmaceutics, Marathwada Mitra Mandals College of Pharmacy, Pune University, Pune, India


 

 

ABSTRACT

The objective of the present study was to formulate a solid self micro emulsifying of drug delivery system (SMEDDS) for oral administration to improve the solubility and bioavailability of Lamotrigine. Solubility was determined in various oils, surfactants and cosurfactants. Ternary phase diagrams were constructed to evaluate the micro emulsification existence area. The optimized formula is obtained by factorial design employed as statistical tool.  The optimal formulation consists of 20% Capmul MCM C8, 55% Labrasol , 25% Tween 80 was adsorbed on carriers Aerosil200, Microcrystalline cellulose (MCC) .The solid SMEDDS are characterized by globule size analysis, and drug release studies of formulations are compared with plain drug. The pharmacokinetic study in rats for the optimized formulation was performed and compared to plain drug powder. SMEDDS have significantly increased the Cmax and area under the curve (AUC) of Lamotrigine compared to powder (P < 0.001). Thus, this self-micro emulsifying drug delivery system should been effective oral dosage form for improving oral bioavailability of Lamotrigine.

Key Words: Solid self-microemulsifying drug delivery system, Globule size, Dissolution, Oral bioavailability

 


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