Mon, 20 Nov 2017

In Vitro Evaluation of Ibuprofen Using Mixed Hydrotrophic Solid Dispersion Approach

 

Kalpana Patidar*1, Mahendra Kshirsagar2, Vipin Saini3, Manish Soni1

1. Research Scholar, Mahatma Jyoti Rao Phoole University, Jaipur, 302001, (Raj.),India,

2. Pataldhamal Wadhwani college of pharmacy, Dhamangaon Road,Yavatmal, 445001, Maharashtra.

3. Maharishi Markandeshwar University, Mullana, Tehsil-Barora, 133207 Ambala, Haryana


 

ABSTRACT

The aim of this study is to enhance the solubility of poorly water soluble drugs via the mixed hydrotrophic solid dispersion strategy using ibuprofen as a model drug because Ibuprofen is absorbed after oral administration, it is critical to improve the dissolution rate to enhance the bioavailability, due to its low water solubility. Solid dispersions were prepared by mixed hydrotrphic method. In vitro dissolution studies showed remarkable improvement in solubility and drug dissolution profile of these new ibupro­fen solid dispersions over pure ibuprofen. It was observed that dissolution rate of ibuprofen enhanced to a great extent by solid dispersion technique using citric acid and urea as a hydrotrophic agents.The results indicates that mixed hydrotrophic solid dispersion may serve as a successful strategy for enhancing solubility of poorly water soluble drugs.

Keywords:  Mixed Hydrotrophic solid dispersions, Solubility, Drug release study, Dissolution


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