Mon, 20 Nov 2017

Synthesis and Antimicrobial Activity of Some Novel Schiff Bases and 4-Thiazolidinones Containing N-Benzyl Piperidine Moiety

 

Chandra Kant Belwal*1, Kaushik A. Joshi 2

1.Department of Chemistry, JJT University, Rajasthan, India

2.M.V.M. Science & Home Science College, Rajkot, India


 

ABSTRACT

A series of novel schiff bases containing N-benzyl piperidine moiety (1a-d) were synthesized by the reaction of N-benzylpiperidine-4-carbaldehyde with suitable aromatic amines. And synthesized schiff bases were converted to a series of novel 4-thiazolidinones (2a-d) by the reaction of Schiff base with mercaptoacetic acid. The chemical structures of the synthesized compounds were confirmed by using spectroscopic and chemical analysis techniques. All the above compounds were screened for their antimicrobial activity against some selected pathogenic microorganism. Good level of antimicrobial activity has been displayed by both categories of compounds against tested pathogenic microorganism. Thiazolidinone derivatives (2a-d) showed higher activity than schiff base derivatives (1a-d).

Keywords: N-benzylpiperidine-4-carbaldehyde, 4-Thiazolidinone, antimicrobial activity, Schiff base, Heterocyclic compounds, N-benzyl piperidine moiety.


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