Mon, 20 Nov 2017

UV Spectrophotometric Method for Simultaneous Determination of Tamsulosin and Finasteride in Combined Dosage Form

 

Mahesh Nasare, Satish. J*, Manikanta Kumar. A, M. Akiful Haque, V.V.L.N.Prasad, Prakash.V. Diwan

1.School of Pharmacy, Anurag Group of Institutions, Venkatapur (V), Ghatkesar (M), Rangareddy (D).


 

ABSTRACT

A simple, rapid and specific UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous determination of tamsulosin and finasteride in bulk and pharmaceutical formulations. In methanol, the lambda max of finasteride and tamsulosin was fixed as 235 and 225nm respectively, using a Shimadzu UV–Visible spectrophotometer (model UV-1800) with quartz cells. In this proposed method both these drugs obeyed linearity individually and in mixture within the concentration range of 1- 10 μg ml-1 for tamsulosin and 12.5 - 100 μg ml-1 for finasteride, with a correlation coefficient value of  0.9992 and 0.9994 for tamsulosin and finasteride respectively. The low relative standard deviation values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method had been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim. The method was validated according to the ICH guidelines.

Keywords: UV spectrophotometric method, finasteride, tamsulosin, simultaneous determination. 


[PDF]  Viewed: 1898  Downloaded: 306
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter