Mon, 20 Nov 2017

Development and Validation of Q–Absorbance Ratio Method for Simultaneous Estimation of Cefixime and Moxifloxacin In Synthetic Mixture

 

B. G. Chaudhari*1, Bhakti Patel1

1.Department of Quality Assurance, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar-384012, Mehsana, Gujarat, India.


 

ABSTRACT

A simple and economical Q-Absorbance spectrophotometric method has been developed for the simultaneous estimation of cefixime and moxifloxacin in their synthetic mixture. The method is based on Q‐absorption Ratio method using two wavelengths, 293.6 nm (λmax of Moxifloxacin) and 276 nm (Isoabsorptive point). Methanol was used as a solvent in the method. Both drugs showed linearity in the range of 4‐14 μg/mL in the methods. The method was validated statistically and recovery studies were carried out. The proposed method was found to be simple, economical, accurate, and reproducible. It can be applied for routine analysis and quality control of both drugs in their combination drug products.

Keywords: Cefixime, Moxifloxacin, Spectrophotometric, Q-absorption Ratio Method


[PDF]  Viewed: 2682  Downloaded: 459
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter