DOI: 10.21276/ajptr
Mon, 25 Mar 2019

Development and Validation of Q–Absorbance Ratio Method for Simultaneous Estimation of Cefixime and Moxifloxacin In Synthetic Mixture


B. G. Chaudhari*1, Bhakti Patel1

1.Department of Quality Assurance, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar-384012, Mehsana, Gujarat, India.



A simple and economical Q-Absorbance spectrophotometric method has been developed for the simultaneous estimation of cefixime and moxifloxacin in their synthetic mixture. The method is based on Q‐absorption Ratio method using two wavelengths, 293.6 nm (λmax of Moxifloxacin) and 276 nm (Isoabsorptive point). Methanol was used as a solvent in the method. Both drugs showed linearity in the range of 4‐14 μg/mL in the methods. The method was validated statistically and recovery studies were carried out. The proposed method was found to be simple, economical, accurate, and reproducible. It can be applied for routine analysis and quality control of both drugs in their combination drug products.

Keywords: Cefixime, Moxifloxacin, Spectrophotometric, Q-absorption Ratio Method

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