Tue, 19 Dec 2017

Recent Advancements in Solubility and Dissolution Enhancement of Simvastatin: A Review

 

Ajay Kumar Sav*1 and Purnima Dhanraj Amin1

1.Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai 400019, India.


 

ABSTRACT

A drug should be present in dissolved or solublized state before producing its therapeutic effect however in current market more than 40% drugs are poorly soluble in water. Such drugs exhibit poor dissolution rate and slow absorption throughout the gastrointestinal tract which leads to irregular bioavailability. Thus various techniques has been adopted for solubility and dissolution enhancement of poor water soluble drugs thereby bioavailability. Solubility plays an important role in achieving the desired plasma drug concentration. In this review article various techniques like solid dispersion, SLNs, SEDDS, dried emulsion were discussed for solubility and dissolution rate improvement of BCS class II anti hyperlipidemic drug Simvastatin. Amongst various method described in this review, solid dispersion was found to be most used technique by researcher as it provide ease in preparation and efficiency in terms of resolving the solubility and dissolution problems associated with Simvastatin.

Keywords: solubility, surfactant, polymers, solid dispersion 


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