Mon, 18 Dec 2017

MBTH (3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride) as a Chromogenic Reagent for Estimation of Faropenem

 

Ameena Sabahath1*, Vanitha Prakash Karnam1, Riaz Shaik1, Jyothsna Duggempudi 1, Anusha Dacha1

1.SSJ College of Pharmacy, V.N. Pally, Gandipet, Hyderabad (India) – 500 075


 

ABSTRACT

A visible spectrophotometric method which is simple, precise and economical has been developed and validated for the estimation of Faropenem in pharmaceutical bulk and tablet dosage form. Identification was carried out using a UV-Visible double beam spectrophotometer with working wavelength at 639.5 nm. It was based on the formation of a colored complex between Faropenem and MBTH (3-Methyl-2-Benzothiazolinone hydrazone hydrochloride) reagent in presence of Ferric chloride. The method was validated with respect to its specificity, linearity range, accuracy, and precision in analytical media. Regression analysis showed good correlation in the concentration range 25-300 μg/ml and the % relative standard deviation as 0.1262. Statistical treatment of data reflects that the proposed method is accurate and easily applicable for determination of Faropenem in bulk and pharmaceutical preparation. The different experimental parameters effecting the development and stability were studied carefully and optimized. A result of analysis for the method was validated statistically and recovery studies were also performed.


[PDF]  Viewed: 3945  Downloaded: 449
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter