DOI: 10.21276/ajptr
Mon, 20 May 2019

MBTH (3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride) as a Chromogenic Reagent for Estimation of Faropenem


Ameena Sabahath1*, Vanitha Prakash Karnam1, Riaz Shaik1, Jyothsna Duggempudi 1, Anusha Dacha1

1.SSJ College of Pharmacy, V.N. Pally, Gandipet, Hyderabad (India) – 500 075



A visible spectrophotometric method which is simple, precise and economical has been developed and validated for the estimation of Faropenem in pharmaceutical bulk and tablet dosage form. Identification was carried out using a UV-Visible double beam spectrophotometer with working wavelength at 639.5 nm. It was based on the formation of a colored complex between Faropenem and MBTH (3-Methyl-2-Benzothiazolinone hydrazone hydrochloride) reagent in presence of Ferric chloride. The method was validated with respect to its specificity, linearity range, accuracy, and precision in analytical media. Regression analysis showed good correlation in the concentration range 25-300 μg/ml and the % relative standard deviation as 0.1262. Statistical treatment of data reflects that the proposed method is accurate and easily applicable for determination of Faropenem in bulk and pharmaceutical preparation. The different experimental parameters effecting the development and stability were studied carefully and optimized. A result of analysis for the method was validated statistically and recovery studies were also performed.

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