DOI: 10.21276/ajptr
Thu, 23 May 2019

Validated RP-HPLC Method for the Estimation of Metoprolol Succinate in Dosage Formulations


L. Venkateswararao1, S.V.M. Vardhan2, S.V. Venkatrao3, Rambabu Chintala1*

1.Department of chemistry,Acharya Nagarjuna University,Guntur,AP,India.

2.Department of Bio-Chemistry, K.U.Dr.MRAR P.G.Centre,Nuzvid,AP, India

3. Rajiv Gandhi University of Knowledge Technologies,Nuzvid,AP,India.



A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the determination of Metoprolol Succinate in dosage formulation. The analyte was resolved by using a mobile phase (Acetonitrile, water and 1 % ortho phosphoric acid in the ratio 70:27:3 v/v/v) at a flow rate 2.0 ml/min on an isocratic HPLC system (Agilent 1100 series with Chemstation software) consisting UV lamp detector, Aligent C-8, RP column (4.6 mm i.d x250 mm) at a wavelength of 280 nm.  The linear dynamic range for Metoprolol Succinate was 10 g/mL–200µg/mL. The limit of detection [LOD]and Limit of quantification[LOQ] for Metoprolol Succinate  was 0.0284µg/mL  and 0.094µg/mL respectively. 

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