DOI: 10.21276/ajptr
Mon, 20 May 2019

Development and Validation of Analytical Methods for Simultaneous Estimation of Pantoprazole Sodium and Levosulpiride in Bulk and their combined dosage form


Tulsi J. Chaudhary*1, Shweta Bhadani1

1.Saraswati Institute of Pharmaceutical Sciences, Dhanap, Gandhinagar,382355, Gujarat-India



A simple, precise, accurate, rapid and economical spectrophotometric method have been developed for simultaneous estimation of Pantoprazole sodium and Levosulpiride in pure and in combined capsule dosage form. Method-1 simultaneous equations and Method-2 Q-absorbance Ratio method by using 287 nm and 231 nm as absorbance maxima (λ max)for Pantoprazole  sodium and Levosulpiride  respectively and 248 nm (isoabsorptive point). A methanol was used as Solvent. Linearity was observed in the concentration range of 5-30 µg/ml for Pantoprazole sodium and 5-30 µg/ml for Levosulpiride. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. 

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