DOI: 10.21276/ajptr
Thu, 23 May 2019

Design and Evaluation of Mucoadhesive Fast Disintegrating Sublingual Tablets Containing Poorly Soluble Drug for Enhancement of Oral Bioavailability


Laxminarayana Adepu 1, 2*, Lakshmi Sirisha Kotikalapudi3, Srinivasa Rao Yerraguntla1, Venkata Ramana Murthy Kolapalli3

1.Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India

2.University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjunanagar, Guntur, India

3.A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India



The aim of this study was to prepare and evaluate sublingual fast-disintegrating mucoadhesive tablet (mFDT) containing a poorly soluble drug (carvedilol CAR) to avoid the first pass metabolism and to improve its bioavailability with reduction in dose and also dose related side effects. The tablets were prepared by direct compression method containing solid dispersion of surfactant and drug. The prepared tablets were tested for weight variation, hardness, drug content uniformity, bioadhesive strength and in vitro drug dissolution. The in vitro release of carvedilol was performed under sink conditions (phosphate buffer of pH 6.8, 37±0.5 ºC, 25 rpm) using USP‐XXIV dissolution apparatus. The acceptable in vitro drug release profile was achieved with the formulation F2 which contains the drug and poloxamer in the ratio of 1:2 and superdisintegrant of 3%. The bioadhesive strength of formulation F2 was found to be 13.8 g. The tablets (formulation F2) containing 6.25 mg of carvedilol exhibited > 80 % of drug release within 10 min. FTIR, XRD and DSC studies showed no evidence of interactions between drug, surfactant, and excipients. The tablets apart from fulfilling all official and other specifications, exhibited higher rate of release. The mucoadhesive fast disintegrating drug delivery system of carvedilol for sublingual delivery could be successfully formulated.

[PDF]   Viewed: 4605   Downloaded: 363
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter