Tue, 19 Dec 2017

Effect of Adjuvants on the Release Pattern of Suppositories Containing Paracetamol

 

Niraj Gupta1*, Shweta Pandey1, HM Varshney1, M.M Gupta1.

1. Jaipur College of Pharmacy, Jaipur, Rajasthan-302022, India


 

ABSTRACT

There is a vast interest in the scientific community and drug industry to exploit various mucosal routes of delivering drugs, which are poorly absorbed after oral administration. Human rectum remains to be a relatively unexplored route of drug delivery despite its potential as a non- invasive route of drug administration. The presence of dense network of blood vessels has made the rectum an excellent route of drug delivery for both systemic and local effect. The present investigation was aimed to evaluating the possibility of using different surfactant i.e. Span 60 and 80, Tween 60 and 80 on the release rate of formulation for the development of rectal drug delivery system of paracetamol, an NSAIDs, to minimize the gastric irritation of the drug upon oral administration. Suppositories were formulated by fusion method & evaluated for their physicochemical characterization followed by in vitro evaluation through spectrophotometrically. Suppositories containing PEG 4000 with Tween 80 showed a better permeation of drug with faster dissolution rate in vitro than other formulations. The formulations were designed to overcome the risk of upper gastrointestinal complications such as stomach bleeding, and may cause kidney or liver damage. Suppositories are dosage forms for use in the unavoidable circumstances such as comatose, nauseous or vomiting.


[PDF]  Viewed: 1199  Downloaded: 110
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter