Tue, 19 Dec 2017

Development and Evaluation of Colon Specific Matrix Tablets of Oxaliplatin combined with Diclofenac sodium

 

Gurbinder Kaur1, Ramachandra Murthy*1

1.Department of Pharmaceutics, I.S.F.College of Pharmacy, Moga, Punjab, India


 

ABSTRACT

Colon specific tablets of Oxaliplatin combined with anti-inflammatory agents, Diclofenac sodium were prepared using guar gum as matrix carriers in varying concentrations from 40% to 65%. The drug combination in the tablet was estimate simultaneously using newly developed and validated UV derivative spectroscopy method. In vitro drug release profile was studied in changing media method, first in 0.1N HCl for two hours followed by 3 hours in phosphate buffer media, pH 7.4 (PB7.4) and in simulated colon fluid (phosphate buffer pH 6.8 added with rat ceacal content) (SCF) for 19 hours. The drug release profiles from PB7.4 and simulated colon fluid were found to be dependent on the gaur gum concentration. Matrix tablets of oxaliplatin and diclofenac sodium combination with 60% w/w Gaur gum showed a total release of ~66% of Oxaliplatin and ~53% of Diclofenac sodium after 24 hrs. The colon tissue homogenate studies conducted after oral administration of the optimized matrix tablet in New Zealand Rabbits showed 156 µg oxaliplatin and 96 µg Diclofenac sodium recovery in 24 hours.  X-ray Images of matrix tablets containing barium sulphate in Rabbit showed tablets to be intact in small intestine (6 hours after administration) but were diffused and spread out in large intestine and colon confirming enzyme mediated erosion of the tablet in these regions. 


[PDF]  Viewed: 1152  Downloaded: 112
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter