Mon, 20 Nov 2017

Design Development and Evaluation of oral thin films of Montelukast Sodium

Roshan C. Chavan1, Raju O. Sonawane1*, Vishal V. Pande1, Laximikant R. Zawar1, Prashant B. Jade1

1.Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.


ABSTRACT

The present study reveals the use of Oral Thin Film (OTF) prepared by solvent casting technique. The prepared Montelukast loaded OTF can be used in emergency condition of severe asthmatic attacks. The comparison study by using Poly (ethylene) Oxide N-750 (PEO) and Hydroxy propyl methyl cellulose E15 (HPMCE15) as film forming polymer was performed. The results obtained for film disintegration and dissolution time tested orally correlated well with those obtained by the visual method. There was considerable reduction in film strength and increase in percent elongation of film with increase in glycerol content. The result showed that film containing PEO N-750 with 5 % glycerol showed better disintegration, dissolution and folding endurance when compared with film containing HPMCE15. Hence, the film containing PEO was used for further optimization where the optimized formulation (F2) depicted disintegration time of less than 6 sec, complete drug release within 8 min, percent elongation as 61.24 cm % and folding endurance more than 250 .

Keywords: Oral thin film (OTF); Montelukast sodium; PEO; HPMCE15


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