DOI: 10.21276/ajptr
Tue, 21 May 2019

Design Development and Evaluation of oral thin films of Montelukast Sodium

Roshan C. Chavan1, Raju O. Sonawane1*, Vishal V. Pande1, Laximikant R. Zawar1, Prashant B. Jade1

1.Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.


The present study reveals the use of Oral Thin Film (OTF) prepared by solvent casting technique. The prepared Montelukast loaded OTF can be used in emergency condition of severe asthmatic attacks. The comparison study by using Poly (ethylene) Oxide N-750 (PEO) and Hydroxy propyl methyl cellulose E15 (HPMCE15) as film forming polymer was performed. The results obtained for film disintegration and dissolution time tested orally correlated well with those obtained by the visual method. There was considerable reduction in film strength and increase in percent elongation of film with increase in glycerol content. The result showed that film containing PEO N-750 with 5 % glycerol showed better disintegration, dissolution and folding endurance when compared with film containing HPMCE15. Hence, the film containing PEO was used for further optimization where the optimized formulation (F2) depicted disintegration time of less than 6 sec, complete drug release within 8 min, percent elongation as 61.24 cm % and folding endurance more than 250 .

Keywords: Oral thin film (OTF); Montelukast sodium; PEO; HPMCE15

[PDF]   Viewed: 2592   Downloaded: 304
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter