Mon, 20 Nov 2017

Hepatoprotective Effect of Alpinia Officinarum on Hepatic Ischemia/Reperfusion Induced Injury in Rats

Indala Rajesh*1, Meenu Singh1, Jagarlamudi Anup1, Vattikuti Uma Maheshwara Rao1, Manupuri Prathyusha1

1.Department of Pharmacology, CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad - 501 401, Andhra Pradesh, India


ABSTRACT

To study the hepatoprotective effect of chloroform extract of Alpinia officinarum at 200 and 400 mg/kg against hepatic ischemia/reperfusion injury. 24 male wistar rats were divided in to four groups. The normal control group, model control group and extract treated group (at a dose of 200 and 400 mg/kg) were orally fed with 1% DMSO, 1% sodium CMC in saline as vehicle for 21 days followed by ischemia/reperfusion on twenty second day. Blood and liver samples were obtained from all the animals on 22nd day for biochemical analysis of AST, ALT, ALP and LDH and histopathological studies were also performed. The results showed that the ischemia/reperfusion injury causes significant (p<0.001) increase in the levels of AST, ALT, ALP and LDH in model control group whereas supplementation with chloroform extract of Alpinia officinarum significantly (p<0.01) reduced the elevated levels of above parameters. Histopathological analysis showed high degree of congestion and mild necrosis in model control group which were reduced to minimum levels in drug treated groups. Alpinia officinarum increased the free radicals scavenging activity in the hepatic I/R injury in rats. Reduced level of liver enzymes and histopathological studies evident that Alpinia officinarum possesses beneficial effect on the hepatocytes against hepatic I/R injury.

Keywords: Ischemia-Reperfusion (I/R) injury, Alpinia officinarum, AST (Aspartate transaminase), ALT (Alanine transaminase), ALP (Alkaline phosphatase) & LDH (Lactate dehydrogenase).


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