DOI: 10.21276/ajptr
Wed, 27 Mar 2019

Development and Validation of UV Spectrophotometric Area Under Curve Method for Estimation of Loratadine in Bulk and Tablet Dosage Form

Hemant Kumar Jain*1, Khushbu H. Patel1
1. STES’s Sinhgad College of Pharmacy, Vadgaon (Bk.), Off. Sinhgad Road, Pune - 411041, Maharashtra, India.


The aim of present work was to develop an accurate, precise, reproducible and economical UV spectrophotometric method for estimation of Loratadine. This method was based on area under curve of UV spectrum between 241 to 251 nm and validated as per ICH guideline Q2 (R1). The method has followed linearity in the range of 5-30µg/ml. The value of correlation coefficient was 0.999. Satisfactory values of Percent relative standard deviation for the intra-day and inter-day precision indicated that method is precise. Results of the recovery studies (99.66 % to 99.95 %) showed accuracy of the method. LOD and LOQ were calculated as 0.581 µg/ml and 1.935 µg/ml, respectively. The developed method can be used for routine estimation of Loratadine in bulk and tablet dosage forms.

Keywords: Loratadine, Estimation, UV spectrophotometry, Area under curve, Validation.

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