Mon, 20 Nov 2017

Determination of Independent Variables for the Losartan Mucoadhesive Buccal Tablets using Central Composite Design

B. Prakash Rao1*, Beny Baby2, Y. Vishnuvardhan Reddy1, S. Rajarajan1, K. Deepthi1K. Ramesh1

1.Department of Pharmaceutical Technology, Karnataka College of Pharmacy, Bangalore, India


ABSTRACT

The Losartan Potassium buccal tablets have been developed as controlled drug delivery systems to improve the efficacy of Losartan Potassium through mucosal absorption, reduce dose frequency, toxicity, to improve bioavailability and patient compliance. Many processing variables can persuade the characteristics of the Losartan Potassium buccal tablets. The aim of the study was to study the effect of some selected process variables in the concentration of drug/locust bean gum, hydroxy propyl methyl cellulose K4M on the hardness, mucoadhesive strength and in-vitro release at different hours by applying central composite design, accounting the above independent variables. The central composite design with an R2 value of 0.9695, 0.9928, 0.5839, and 0.7556 has selected as a suitable model for further analysis. The model F value of 44.52, 277.61, 7.02, 15.46 with probability P>F<0.0500 implies that this model is significant. The hardness, mucoadhesive strength and in vitro studies are prejudiced by mainly basic formulation factors which consist of drug/polymer ratio. Findings established the role of statistical design in predicting the values of independent variables for preparation of Losartan Potassium buccal tablets having pre determined hardness, mucoadhesive strength and in vitro studies.

Keywords: Mucoadhesive, central composite design, hydroxypropyl methyl cellulose K4M, locust bean gum, Losartan Potassium.


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