DOI: 10.21276/ajptr
Wed, 27 Mar 2019

Comparative Effect of Antidepressants (Desipramine) and NSAID (Dexibuprofen) Against Chronic Pain and Depression Associated with MIA Induced Osteoarthritis in Rats.

VS. Saravanan*1 ,V.Krishnaraju1

1. Erode college of Pharmacy Erode – 638112.


To compare the role of anti-depressants (Desipramine) and NSAID (Dexibuprofen) in monosodium iodo acetate (MIA) induced chronic knee osteoarthritis (OA) in rats. Twenty four male wistar rats were divided into 4 groups of 6 animals each. Group I to IV served as Vehicle control, OA control, Desipramine and Dexibuprofen treated groups respectively. Group I received I.A. Injection of 50µl of  0.9%normal saline, and Group II to IV received I.A. Injection of 50µl MIA, and the treatment of drugs started on the same day. The animals will be monitored for  osteoarthritis parameters and/or depression on pre-dose day (day 0) and on day 1, 3, 5, 7, 11  14, 18, 21 and 28 th day. The rise in knee inflammation is almost similar in all MIA treated groups (p<0.001) on day 3. The inflammation reached to normal on day 7 and  has slightly increased in desipramine group  on day 7 to day 14, whereas the fluctuation is not seen in dexibuprofen group. Dexibuprofen increased Vocalization threshold of knee compression force for 7 days and decreased the rafter whereas desipramine has no effect for first 7 days and increased the rafter. Desipramine was significantly (p<0.001) effective on neuropathic pain (Punctate allodynia,  mechanical grip strength,  threshold angle of knee extension) and depression  (forced swim test and locomotor activity) compared to dexibuprofen. The present study has shown that dexibuprofen has the potential in the initial phase of chronic OA and desipramine  in the later stage, where neuropathic and depressive component dominates.

Keywords: Osteoarthritis, Depression, MIA,  Desipramine  and Dexibuprofen 

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