DOI: 10.21276/ajptr
Wed, 27 Mar 2019

Synthesis and Antimicrobial Activity of Piperazine Derivatives

Somashekhar M1*, Mahesh AR1

1.Krupanidhi College of Pharmacy. Bangalore, Karnataka- 560035, India.


Ethyl piperazine is treated with 4- chloro nitrobenzene in presence of anhydrous potassium carbonate and methanol is used as a solvent forms 1 ethyl -4-[4-nitrophenyl] piperazine, then it is treated with iron dust in presence of hydrochloric acid and neutralized with sodium carbonate to form the 4-[4-ethyl piperazine-1-yl] anilline, it is reacted with n-chloro acetyl aryl amine in presence of  anhydrous potassium carbonate forms the final product  1-[2-(aryl amino -2-oxoethyl ) - amino -4-(n-ethyl piperazine)] benzene derivatives were synthesized, the synthesized compounds were screened for their antibacterial activates against s. aures and e.coli by cup plates method . From screening results of some compounds found highly active against both gram – positive and gram – negative bacteria while other compounds possess moderate activity.

Keywords: Ethyl Piperazine, Potassium Carbonate, N-Chloro Acetyl Aryl Amine.

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