Mon, 20 Nov 2017

Formulation and in-vitro Evaluation of Ciprofloxacin Hydrochloride Sustained Release Tablets using various Viscosity Grades of Hydroxypropyl Mythylcellulose

Sunil Kumar Padhy1*, Debashrita Sahoo1, Debadatta Acharya1, Jharna Mallick2, Sradhanjali Patra3

1.Formulation Research & Development, Caplin Point Laboratories Ltd., T. Nagar, Chennai.

2. Department of Pharmaceutics, Vision college of Pharmaceutical Sciences & Research, Boduppal, Hyderabad , Andhra Pradesh - 500092

3. University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha


ABSTRACT

The primary objective of sustained release drug delivery system is to ensure safety and to improve efficacy of drugs as well as patient compliance. Using controlled drug delivery system the drug release pattern can be controlled within narrow therapeutic range, which leads to minimize the side effect and ensure the safety. The aim of the study is to design, characterize and evaluate ciprofloxacin hydrochloride sustained release tablets using various viscosity grades of HPMC. As ciprofloxacin HCl has very short half life (nearly 3½ to 4 hr) hence multidose therapy for conventional tablets, (250 mg, 500 mg twice a day) is necessary to get the desired therapeutic level. Hence in the presence study attempt has been made to formulate the sustained release tablets of ciprofloxacin HCl using different viscosity grades of HPMC i.e. HPMC K4m,  HPMCK15M, HPMC K100M with different drug polymer ratio to reduce the dosing frequency, minimize the flections of plasma drug concentration, evaluation has been done of the prepared formulation and compared with the standard. The prepared granules were free flowing and characterized for drug content, DSC, X-ray diffraction study and FTIR. The X-ray diffraction study & DSC obtained from various formulations showed no interaction within these formulations. The in-vitro release studies were performed using pH 7.4 phosphate buffer for 12 hours from which the different drug polymer ratios are followed zero order kinetics.

Keywords: Differential Scanning Calorimetry, X-ray diffraction study, Hydroxyl propyl Methyl Cellulose, zero order kinetics


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