DOI: 10.21276/ajptr
Tue, 21 May 2019

Synthesis, Characterization and Evaluation of Some 1, 3 Thiazine Derivatives as Possible Antimicrobial Agents

Beena KP*1, Sooraj TV1, Nissy Susan Abraham1, Rishana P1, Akelesh T2.

1.KMCH College of Pharmacy, Kovai Medical Centre Research and Educational Trust, Kovai Estate, Kalapatti Road, Coimbatore, Tamilnadu,

2. RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamilnadu, India


A series of [6-(p-substituted aminophenyl)-4-(p-substituted phenyl)—6H-1,3 thiazin-yl]-acetamides were synthesized via Claisen-Schmidt condensation. The titled compounds were characterized by IR, NMR analysis. The synthesized compounds were screened for their antibacterial and antifungal activity disc diffusion method. Among the synthesized compounds, T-2 was found to have a strong antibacterial and antifungal activity. Compounds T-1, T-3, T-4 and T-5 were found to have promising antimicrobial activity.

Keywords: Thiazines, Acetamides, Claisen-Schmidt Reaction, Antibacterial, Antifungal

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