Mon, 20 Nov 2017

Recent Advances in the Synthesis of 2H-1,4-pyridoxazin-3-(4H)-one Derivatives and its Pharmaceutical Significance

Amar Deep Ankalgi1* , Mahendra Singh Ranawat1

1. Department of Pharmaceutical Chemistry, Bhupal Nobles’ College of Pharmacy, Udaipur(Raj.)-India


ABSTRACT

The wide occurrence of benzo fused and heterocyclic fused [1,4] oxazines in bioactive natural product and pharmaceuticals have made them important synthetic targets. 2H-1,4-pyridoxazin-3-(4H)-one   has been studied intensively as important heterocyclic systems for building natural and designed synthetic compounds. They are utilized as suitable skeletons for the design of biologically active compounds, ranging from anti-inflammatory, analgesics, bacteriostatic, fungistatic and MAO inhibitors etc. Various researchers with help of organic and analytical chemistry developed 2H-1,4-pyridoxazin-3-(4H)-one using different synthetic route.

Keywords: anti-inflammatory, bacteriostatic, MAO inhibitors


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