DOI: 10.21276/ajptr
Fri, 21 Jun 2019

Spectrophotometric Estimation of Tolterodine Tartarate In Bulk And Tablet Dosage Form

Amruta B. Loni1, Anita Hosmani1, Apurwa Gote1, Pooja A. Guled1, Sandhya C. Jeurkar1, Smita T. Kumbhar1*.

1.Department of Pharmaceutical Analysis, DSTS Mandal’s College of Pharmacy, Solapur-413004, India


A simple, precise and economical UV Spectrophotometric method has been developed for the estimation of Tolterodine tartarate in bulk and pharmaceutical dosage form. The method is based on measurement of absorption at maximum wavelength of 283.0 nm. Linearity for detector response was observed in the concentration range of 10-50 μg/ml. The accuracy of the method was assessed by recovery studies and was found to be 99.80%. The LOD and LOQ were found to be 0.1865 and 0.5621 respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision, specificity and robustness and ruggedness. The results were validated statistically as per ICH Q2 R1 guideline and were found to be satisfactory. The proposed method was successfully applied for the determination of Tolterodine tartarate in commercial pharmaceutical dosage form.

Keywords: Tolterodine tartarate, UV Spectrophotometry, validation.


[PDF]   Viewed: 1244   Downloaded: 130
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter