DOI: 10.21276/ajptr
Tue, 25 Jun 2019

In-Vivo Healing Potential of Punica Granatum and Glycyrrhiza Glabra on Excisional Dermal Wounds

Varsha B. Bagade1*, Varsha M. Jadhav1, Vilasrao J. Kadam 1

1. Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, C.B.D Belapur,  Navi Mumbai - 400614, Maharashtra, India.


The methanolic extract of Punica granatum (PUG), Glycyrrhiza glabra (GLA) and their combination (PUG-GLA) were evaluated for their wound healing activity using excision wound model in rats. Rats treated with PUG-GLA showed higher rate of wound contraction, significant decrease in epithelization period and significant increase in hydroxyproline content of granulation tissue when compared with the controls. The histological examination of treated wounds showed that the original tissue regeneration was much greater in PUG-GLA, with increase in the restoration of collagen fibers, fibroblasts, blood vessel formation and hair follicle regeneration.

Keywords: Punica granatum; Glycyrrhiza glabra; Wound healing; Excision model; Hydroxyproline 

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