Mon, 20 Nov 2017

Aceclofenac Loaded Solid Lipid Microparticle: Preparation, Characterization & In-Vitro Study

Dilip Patel1*, Roohi Kesharwani1, Bhaskar Mazumder2

1 Chandra Shekhar Singh College of Pharmacy, Kausambi, Allahabad, U.P. India.

2 Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India.


ABSTRACT

The aim of the study is to prepare solid lipid Microparticle (SLM) dispersion of aceclofenac for the treatment of inflammation and allied condition. SLM prepared by melt emulsification & solvent evaporation methods were characterized by Malvern instrument for particle size and particle size distribution and zeta potential analysis. The particle size of dispersion was further confirmed by scanning electron microscopy (SEM) studies. IR study of pure drug, Stearic acid and drug loaded solid lipid Microparticle were performed. In-vitro release study was performed on modified franz diffusion assembly which showed that drug release maximum 79.86% in 24 hours.

Keywords; Aceclofenac, Solid lipid Microparticle (SLM), Microparticle, Lipid Microparticle


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